2-Hydroxy Oleic Acid
≥98% (HPLC)
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Used in pharmaceutical research for its potential anticancer properties, particularly in targeting lipid metabolism in tumor cells. It has shown activity in modulating cell membrane composition by inhibiting sphingomyelin synthase, leading to decreased sphingomyelin levels and induction of apoptosis in cancer cell lines. Investigated for use in treating glioblastoma, breast cancer, pancreatic cancer, and other solid tumors due to its effects on signal transduction pathways. Also demonstrates potential in reducing drug resistance in cancer cells, enabling more effective combination with other chemotherapies. Preclinical studies indicate acceptable safety profiles compared to standard chemotherapies.
Additionally, explored in dermatological formulations for its skin-conditioning and barrier-enhancing effects. Its amphiphilic nature allows integration into liposomal drug delivery systems, improving stability and cellular uptake of active compounds. Studied for neurological applications, such as Alzheimer's disease, due to its influence on myelin formation and function in the central nervous system. Currently in clinical trials, requiring further data to confirm efficacy and safety in humans.
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