Cilengitide
98%
Reagent
Code: #159681
CAS Number
188968-51-6
blur_circular Chemical Specifications
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Molecular Information
Weight
588.66 g/mol
Formula
C₂₇H₄₀N₈O₇
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Registry Numbers
MDL Number
MFCD04307743
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Storage & Handling
Storage
-20°C
description Product Description
Used in research for treating solid tumors, particularly glioblastoma. Acts as an inhibitor of integrins αvβ3 and αvβ5, which play key roles in tumor angiogenesis and cancer cell survival. By blocking these integrins, it disrupts blood vessel formation in tumors and can induce apoptosis in cancer cells. Has been evaluated in clinical trials for brain cancers, often in combination with radiation and chemotherapy. Also studied for anti-angiogenic effects in other cancers and ocular diseases involving abnormal blood vessel growth.
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