Nedaplatin is primarily used in the treatment of various types of cancer, particularly in cases where other platinum-based chemotherapeutic agents may be less effective or unsuitable. It is commonly administered for head and neck cancers, lung cancer, and esophageal cancer. The drug works by interfering with DNA replication in cancer cells, ultimately leading to cell death. It is often preferred in certain clinical scenarios due to its potentially lower nephrotoxicity compared to other platinum compounds, making it a safer option for patients with compromised kidney function. Additionally, nedaplatin is sometimes used in combination with radiation therapy to enhance its efficacy in localized tumors. Its application is carefully monitored to manage side effects such as myelosuppression and gastrointestinal disturbances.