Widely used in solid-phase oligonucleotide synthesis, this compound acts as a phosphitylating agent to form phosphoramidite monomers. It enables efficient and selective coupling to nucleosides, facilitating the construction of DNA and RNA sequences with high yield and purity. Its reactivity and stability under anhydrous conditions make it ideal for automated synthesizers used in genetic research, diagnostics, and development of antisense therapeutics. Additionally, it supports the introduction of specific modifications in oligonucleotides, such as labeled probes or backbone alterations, enhancing their utility in molecular biology and pharmaceutical applications.