5'-O-DMT-N2-(dimethylamino)methylidene-2'-deoxyguanosine
98%
science Other reagents with same CAS 40094-22-2
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description Product Description
Used primarily in oligonucleotide synthesis, this chemical acts as a protected form of deoxyguanosine. The DMT (dimethyltrityl) group safeguards the 5'-hydroxyl during the synthesis process, while the dimethylamino methylidene moiety protects the exocyclic amine of the guanine base. This protection strategy is crucial for the stepwise assembly of DNA sequences in solid-phase synthesis, ensuring high yield and purity of the final oligonucleotide product. It is particularly valuable in the production of primers, probes, and therapeutic oligonucleotides for applications in research, diagnostics, and drug development.
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