This chemical is widely used in the synthesis of modified nucleosides, which are crucial in the development of oligonucleotides for therapeutic and research purposes. It serves as a protected intermediate in the preparation of antisense oligonucleotides, which are designed to target specific RNA sequences to modulate gene expression. Additionally, it is employed in the synthesis of nucleotide analogs used in antiviral and anticancer drug development. The tert-butyldimethylsilyl (TBDMS) group provides protection for the hydroxyl group during chemical reactions, ensuring selective modification of the nucleoside. This compound is particularly valuable in solid-phase oligonucleotide synthesis, where precise control over the sequence and structure of the synthesized nucleic acids is essential. Its application extends to the study of DNA repair mechanisms and the development of diagnostic tools for genetic disorders.