2'-deoxy-2'-fluoro-2'-C-methyluridine
10mM in DMSO
Reagent
Code: #157804
CAS Number
863329-66-2
blur_circular Chemical Specifications
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Molecular Information
Weight
260.22 g/mol
Formula
C₁₀H₁₃FN₂O₅
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Registry Numbers
MDL Number
MFCD19982668
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Storage & Handling
Storage
-20°C
description Product Description
Used in antiviral therapy, particularly in the treatment of hepatitis C virus (HCV) infections. It acts as a nucleoside analog that inhibits viral RNA replication by targeting the viral RNA-dependent RNA polymerase. Once phosphorylated inside host cells, the compound incorporates into the growing RNA chain, causing premature termination due to its modified sugar moiety. This mechanism reduces viral load and supports clearance of HCV. It has been explored as a key component in combination therapies to improve treatment efficacy and reduce the likelihood of drug resistance. Its structural modifications enhance metabolic stability and selectivity for viral enzymes over host cell polymerases, contributing to a favorable safety profile.
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