Used in solid-phase oligonucleotide synthesis to introduce a 2'-fluoro-modified inosine residue into RNA strands. This modification enhances nuclease resistance and improves binding affinity in antisense technologies and RNA interference applications. The dimethoxytrityl group provides protection during synthesis and allows for efficient monitoring of coupling efficiency. The phosphoramidite group enables rapid and precise incorporation into the growing oligonucleotide chain using automated synthesizers. Commonly applied in the development of therapeutic oligonucleotides, diagnostic probes, and functional RNA molecules with increased stability and specificity.