Used in the synthesis of modified oligonucleotides for antisense therapy and RNA interference (RNAi) applications. The 2'-O-propynyl group enhances binding affinity to complementary RNA strands, improving target specificity and nuclease resistance. The DMT (dimethoxytrityl) group enables real-time monitoring during solid-phase oligonucleotide synthesis by allowing detection of coupling efficiency. The phosphoramidite moiety facilitates automated stepwise assembly of nucleic acid chains, making it essential for producing therapeutic oligonucleotides with improved stability and biological activity. Commonly applied in the development of pharmaceuticals targeting genetic disorders, cancers, and viral infections.