Used in solid-phase oligonucleotide synthesis, particularly for the preparation of modified RNA strands. Its main application lies in introducing a protected guanosine derivative at specific positions in RNA sequences, enabling the creation of stable, functional RNA molecules such as antisense oligonucleotides, siRNA, and mRNA caps. The DMT and silyl protecting groups allow stepwise chain elongation and prevent unwanted side reactions during synthesis. The phosphoramidite group facilitates efficient coupling to the growing nucleic acid chain. This compound is essential for producing RNA with enhanced nuclease resistance and improved binding affinity, which are critical in therapeutic and diagnostic applications.