Used in the solid-phase synthesis of modified oligonucleotides, particularly in the preparation of antisense therapeutics and siRNA. The 2'-fluoro modification enhances nuclease resistance and improves binding affinity to complementary RNA strands. The DMT (dimethoxytrityl) group enables real-time monitoring of coupling efficiency during synthesis by UV detection. The phosphoramidite functionality allows for automated incorporation into DNA/RNA sequences using standard oligonucleotide synthesizers. This compound is essential for introducing 2'-fluoro-arabino nucleic acid (FANA) residues, which are explored in gene silencing, diagnostic probes, and therapeutic development due to their favorable stability and hybridization properties.