Used in solid-phase oligonucleotide synthesis, particularly for the preparation of RNA strands. It enables the selective addition of nucleotides by protecting the 2′-hydroxyl group during chain assembly, preventing unwanted side reactions. The benzoyl group protects nucleobases like adenine, ensuring fidelity in sequence construction. Its compatibility with automated synthesizers makes it essential for producing high-purity RNA for research, diagnostics, and therapeutic applications such as antisense oligonucleotides and RNA interference.