Used in oligonucleotide synthesis, particularly in the preparation of modified DNA or RNA strands for research and therapeutic applications. It enables the introduction of specific functional groups into nucleic acid sequences, enhancing stability, binding affinity, or biological activity. Commonly applied in the development of antisense oligonucleotides, siRNA, and molecular probes where precise modifications are critical for performance. Its phosphoramidite group allows for efficient coupling during solid-phase synthesis, making it valuable in automated DNA/RNA synthesizers.