Used in the synthesis of oligonucleotides for molecular biology and genetic research. Enables the incorporation of modified nucleotides into DNA strands, particularly in automated solid-phase synthesis. The dimethoxytrityl (DMT) group protects the 5'-hydroxyl during chain elongation, while the phosphoramidite group allows for efficient coupling. Commonly applied in the development of probes, primers, and antisense molecules where precise control over nucleotide modification is required. Also useful in diagnostic assays and therapeutic oligonucleotide design due to enhanced stability and specificity.