Used in solid-phase oligonucleotide synthesis, this phosphoramidite reagent enables the introduction of a lipophilic palmitoyl group into nucleic acid constructs. The modification enhances membrane permeability of synthetic oligonucleotides, making it valuable for developing therapeutic antisense agents, siRNA, and other modified nucleic acids where cellular uptake is critical. The cyanoethyl group stabilizes the phosphite during synthesis and is removed during standard deprotection. Its dual functionality allows for efficient coupling and improved pharmacokinetic properties in final oligonucleotide products.