Used in solid-phase oligonucleotide synthesis for the preparation of modified DNA sequences. The 8-bromo modification stabilizes guanine in the syn conformation, enabling studies of DNA structure and function, particularly in Z-DNA formation and G-quadruplex folding. The DMT and CE phosphoramidite groups allow for stepwise chain elongation and efficient coupling in automated synthesizers. Commonly applied in antisense technology, nucleic acid probes, and epigenetic research where halogenated bases influence hybridization and protein binding.