Used extensively in the synthesis of oligonucleotides, it serves as a protecting group for the 5'-hydroxyl group of adenosine during solid-phase synthesis. This protection is crucial to prevent unwanted side reactions and ensure the correct sequence assembly in DNA and RNA synthesis. It is particularly valuable in the production of modified nucleosides and nucleotides for research in molecular biology and therapeutic applications. Its stability under various reaction conditions makes it a reliable choice for complex synthetic pathways. Additionally, it is employed in the development of antisense oligonucleotides and siRNA, which are pivotal in gene silencing and therapeutic interventions targeting specific genetic disorders.