((2R,3S,5R)-3-Acetoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate
98%
Reagent
Code: #228753
CAS Number
6979-97-1
blur_circular Chemical Specifications
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Molecular Information
Weight
326.3 g/mol
Formula
C₁₄H₁₈N₂O₇
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Registry Numbers
MDL Number
MFCD00010630
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Physical Properties
Melting Point
126-128 °C
Boiling Point
463.51 °C
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Storage & Handling
Density
1.2368 g/cm3
Storage
2-8°C, sealed, dry, light-proof
description Product Description
Used as a protected intermediate in the synthesis of antiviral nucleoside analogs, particularly for retroviral treatments such as HIV. This compound, a diacetylated form of 2'-deoxythymidine, facilitates selective chemical modifications in the preparation of drugs like zidovudine (AZT), which inhibits reverse transcriptase to prevent viral replication. Its defined stereochemistry (β-D configuration) ensures proper incorporation into pharmaceutical intermediates, improving synthetic efficiency. Also employed in oligonucleotide synthesis for research and diagnostic applications, contributing to the construction of DNA sequences.
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