Used in the synthesis of oligonucleotides for research and pharmaceutical development, particularly in antisense therapy and RNA interference. Acts as a protected nucleoside building block, where the bis(4-methoxyphenyl)phenylmethyl group shields the 5′-hydroxyl during solid-phase synthesis, ensuring correct sequence assembly. The protecting group is later removed under mild acidic conditions without damaging the nucleobase or sugar backbone. Commonly applied in the production of modified RNA strands for studying gene expression or developing therapeutic nucleic acids.