Used as a key intermediate in the synthesis of oligonucleotides for antisense therapy and RNA interference (RNAi) applications. The tert-butyldimethylsilyl (TBDMS) protecting groups selectively shield the 2′ and 3′ hydroxyl sites on the ribose ring, allowing controlled phosphoramidite coupling during solid-phase oligonucleotide synthesis. This protection is stable under standard synthesis conditions and can be removed selectively without affecting other functional groups, making it valuable in the production of modified nucleic acids for therapeutic and diagnostic use.