GSK4112 is primarily used in research settings to study the REV-ERB nuclear receptor, which plays a significant role in regulating circadian rhythms and metabolism. It acts as a synthetic ligand, helping scientists understand the receptor's function and its impact on biological processes like sleep, metabolism, and inflammation. This compound is particularly valuable in exploring potential therapeutic applications for metabolic disorders, sleep disorders, and inflammatory diseases. Its use in preclinical studies provides insights into the development of drugs targeting circadian rhythm-related conditions.