Nisoxetine hydrochloride is primarily used in research settings to study the mechanisms of neurotransmitter reuptake inhibition, particularly norepinephrine. It serves as a selective norepinephrine reuptake inhibitor (NRI), making it valuable for understanding the role of norepinephrine in various physiological and psychological processes. Researchers utilize it to explore its effects on mood regulation, attention, and stress responses, contributing to advancements in neuroscience and pharmacology. Additionally, it is employed in preclinical studies to model and investigate conditions such as depression, anxiety, and ADHD, aiding in the development of potential therapeutic interventions. Its specificity for norepinephrine transporters makes it a useful tool for dissecting the noradrenergic system's involvement in brain function and behavior.