Used primarily in neuroscience research, this compound acts as a highly selective antagonist for the GluN2B subunit of NMDA receptors. It is valuable for studying synaptic plasticity, neuronal excitotoxicity, and mechanisms underlying neurodegenerative diseases such as Alzheimer's. Due to its specificity, it helps researchers isolate GluN2B-mediated signaling pathways in brain function and behavior. It is also employed in preclinical studies exploring potential treatments for stroke, chronic pain, and depression, where NMDA receptor overactivity plays a role. Its application enables targeted modulation of NMDA receptor activity without broadly affecting all NMDA receptor subtypes.