Used primarily in neuroscience research as a selective antagonist of the NMDA receptor, particularly targeting the GluN2B subunit. This makes it valuable for studying excitotoxicity, synaptic plasticity, and neurodegenerative conditions such as stroke and Alzheimer's disease. It is also investigated for its potential in modulating glutamate-related pathways involved in chronic pain and addiction. Due to its ability to cross the blood-brain barrier, it serves as a tool compound in preclinical models to explore cognitive and behavioral effects linked to NMDA receptor dysfunction.