Used as a potent and selective antagonist at the glycine site of the NMDA (N-methyl-D-aspartate) receptor in neuroscience research. It helps investigate the role of NMDA receptor activity in processes like synaptic plasticity, learning, memory, and neurodegenerative conditions. Due to its ability to cross the blood-brain barrier when administered in prodrug form, it is valuable in behavioral and pharmacological studies exploring excitatory neurotransmission. Also employed in studies related to epilepsy, schizophrenia, and chronic pain, where modulation of glutamatergic signaling is relevant.