4-Fluoro-2-(trifluoromethyl)benzonitrile
>98.0%(GC)
Reagent
Code: #187262
Alias
4-fluoro-2-(trifluoromethyl)benzonitrile;
2-trifluoromethyl-4-fluorobenzidine;
4-fluoro-2-(trifluoromethyl)benzidine;
2-Cyano-5-fluorotrifluorotoluene
CAS Number
194853-86-6
blur_circular Chemical Specifications
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Molecular Information
Weight
189.11 g/mol
Formula
C₈H₃F₄N
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Registry Numbers
MDL Number
MFCD00061283
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Physical Properties
Melting Point
43-45°C
Boiling Point
53°C 15mm
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Storage & Handling
Density
1.35 g/cm3
Storage
Room temperature, flammable area
description Product Description
Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of fluorinated active pharmaceutical ingredients (APIs) where the fluorine atoms enhance metabolic stability and bioavailability. Its nitrile and fluorinated aryl groups make it valuable in agrochemicals, especially in herbicides and insecticides, contributing to improved lipophilicity and target binding. Commonly employed in medicinal chemistry for structure-activity relationship (SAR) studies due to its ability to modulate electronic and steric properties. Also utilized in the preparation of liquid crystals and functional materials where fluorinated aromatic building blocks are required for thermal and chemical stability.
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