PNU-282987 is primarily utilized in research settings to study the effects of nicotinic acetylcholine receptors (nAChRs) in the central nervous system. It is often employed as a selective agonist for the α7 subtype of these receptors, helping to investigate their role in cognitive functions, memory, and neuroprotection. This compound is particularly useful in exploring potential therapeutic applications for neurodegenerative diseases such as Alzheimer's and schizophrenia, as well as in understanding the mechanisms underlying nicotine addiction. Additionally, PNU-282987 is used in experimental models to assess its anti-inflammatory and neuroprotective properties, contributing to advancements in neurological and psychiatric research.