Nickel(II) trifluoromethanesulfonate is widely used as a catalyst in organic synthesis, particularly in cross-coupling reactions, where it facilitates the formation of carbon-carbon bonds. It is effective in promoting reactions such as the Suzuki-Miyaura and Negishi couplings, which are essential for constructing complex organic molecules in pharmaceuticals and agrochemicals. Additionally, it serves as a Lewis acid catalyst in various polymerization processes, enabling the production of high-performance polymers. Its stability and solubility in organic solvents make it a versatile choice for catalytic applications in both academic research and industrial settings.