Nickel boride is widely used as a catalyst in organic synthesis, particularly for hydrogenation reactions. It selectively reduces functional groups such as alkenes, alkynes, nitriles, and carbonyls under mild conditions. It is especially valued in the reduction of nitro groups to amines and in reductive amination processes. Compared to other metal catalysts, nickel boride offers good activity without requiring high pressure or temperature, making it suitable for lab-scale and industrial applications. It is also employed in cross-coupling reactions and has been explored in electrochemical applications due to its conductive and catalytic properties. Its in-situ preparation allows for flexibility in reaction design, enhancing its utility in synthetic chemistry. Additionally, it is used in hydrodesulfurization processes to remove sulfur from certain organic compounds and in surface coating applications to improve corrosion resistance.