Used in research settings as a selective sigma receptor ligand, particularly showing affinity for the sigma-1 receptor subtype. It is employed to study neurological pathways involved in pain perception, neuroprotection, and psychiatric disorders such as depression and anxiety. Due to its ability to modulate cellular signaling and ion channel activity, RHO-15 serves as a tool compound in exploring the role of sigma receptors in neurodegenerative diseases and addiction mechanisms. Its application remains primarily confined to preclinical investigations and in vitro models.