NBI 27914 is primarily used in scientific research as a selective antagonist for the neurotensin receptor, particularly the NT1 subtype. It helps investigators study the role of neurotensin signaling in various physiological and pathological processes, including pain modulation, schizophrenia, drug addiction, and regulation of body temperature. Due to its ability to cross the blood-brain barrier, NBI 27914 is valuable in central nervous system studies, allowing researchers to assess behavioral and neurochemical effects of blocking neurotensin activity in vivo. Its application supports the development of potential therapeutics targeting neurotensin pathways, especially in psychiatric and neurological disorders.