Used in research to study histamine receptor activity, particularly H1 and H2 receptors, due to its ability to mimic or modulate histamine effects. Commonly employed in pharmacological assays to investigate allergic responses, gastric acid secretion, and immune system activation. Also utilized in the development and testing of antihistamines and anti-ulcer drugs. Its R(-)-alpha-methyl modification enhances receptor selectivity and metabolic stability, making it valuable in structure-activity relationship studies.