HJC0152 is primarily used in research settings as a potent and selective antagonist for the orexin receptor system, specifically targeting the OX1 receptor. It is utilized to study the role of orexin signaling in various physiological processes such as sleep-wake regulation, appetite control, and reward-related behaviors. Due to its high selectivity and blood-brain barrier permeability, HJC0152 is valuable in neuroscience research for investigating conditions like insomnia, addiction, and anxiety. It enables researchers to dissect the contribution of OX1 versus OX2 receptors in behavioral models, making it a critical tool compound in the development of novel therapeutics targeting orexin pathways.