Efaroxan hydrochloride is primarily used in scientific research as a selective antagonist for alpha-2 adrenergic receptors. It helps in studying the role of these receptors in neurotransmission, particularly in the central nervous system. Due to its ability to block alpha-2 receptors, it is employed in experiments investigating noradrenaline release, synaptic modulation, and neuronal excitability. It has also been used to explore potential antidepressant and neuroprotective mechanisms in preclinical models. Its application remains largely confined to laboratory and pharmacological research, with no widespread clinical use.