Used in pharmaceutical research as a potent and selective antagonist of the orexin receptor, particularly OX1R. It is utilized in studies related to sleep disorders, such as insomnia, due to the role orexin plays in regulating wakefulness. Commonly employed in preclinical studies to evaluate the effects of orexin inhibition on sleep architecture, arousal, and related neurological functions. Also used as a reference compound in pharmacokinetic and metabolic stability assays during drug development. Its structure allows for high blood-brain barrier penetration, making it valuable for central nervous system-targeted therapies.