Corynoxine is an indole alkaloid derived from plants in the Uncaria genus, commonly used in traditional Chinese medicine (TCM) to help lower blood pressure through its vasodilatory effects, which promote blood circulation. It is frequently combined with other herbs to relieve symptoms such as dizziness and headaches associated with hypertension. In modern research, corynoxine is primarily studied for its potential neuroprotective effects, particularly in relation to brain health and neurological disorders. It has shown promise in promoting the clearance of damaged proteins in neurons, which may help in the management of neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases. Research suggests that corynoxine can activate cellular pathways involved in autophagy—the process by which cells remove and recycle dysfunctional components—supporting neuron survival and function. Due to this mechanism, it is being explored as a candidate for drug development in neurodegenerative disease therapy. Additionally, it may influence dopamine systems, which could contribute to its potential in improving motor control and cognitive function in preclinical models. Most current applications remain in the experimental and research phase, with studies focused on understanding its efficacy and safety in neurological treatments.