Cyclo(His-Pro) TFA is primarily studied for its neuroprotective and neuromodulatory properties. It has shown potential in improving cognitive function and memory retention, making it of interest in research related to neurodegenerative disorders such as Alzheimer's disease. The compound may influence neurotransmitter systems, particularly dopamine regulation, which suggests possible applications in managing symptoms of Parkinson’s disease. It also exhibits metabolic stability and the ability to cross the blood-brain barrier efficiently, enhancing its suitability for central nervous system-targeted therapies. Additionally, Cyclo(His-Pro) TFA has been investigated for its role in reducing oxidative stress and inflammation in neural tissues, further supporting its therapeutic potential in brain injury and stroke models. Due to its structural similarity to endogenous peptides, it is used in studies exploring appetite regulation and energy homeostasis. Its trifluoroacetate salt form improves solubility and bioavailability, which is beneficial for in vitro and in vivo research applications.