Rat CGRP-(8-37) is a peptide fragment derived from calcitonin gene-related peptide (CGRP) and is primarily used in research settings to study the physiological and pathological roles of CGRP. It acts as a competitive antagonist of CGRP receptors, making it a valuable tool for investigating the involvement of CGRP in various biological processes.

In neuroscience, it is utilized to explore the role of CGRP in pain transmission, particularly in migraine pathophysiology. By blocking CGRP receptors, it helps researchers understand how CGRP contributes to vasodilation, neurogenic inflammation, and pain signaling. This knowledge aids in the development of targeted therapies for migraine and other pain disorders.

Additionally, Rat CGRP-(8-37) is employed in cardiovascular research to study the effects of CGRP on blood pressure regulation and vascular tone. It helps elucidate the peptide's role in conditions like hypertension and heart failure.

In gastrointestinal studies, it is used to investigate CGRP's influence on gut motility and secretion, providing insights into digestive disorders. Overall, Rat CGRP-(8-37) is a critical tool for dissecting the complex functions of CGRP in various physiological systems.