Substance P is widely used in research to study its role in pain transmission and neuroinflammation. It is applied in experimental models to investigate its effects on the nervous system, particularly in conditions like chronic pain, migraines, and arthritis. In pharmacology, it serves as a target for developing drugs that block its receptor, the neurokinin-1 receptor, to alleviate pain and inflammation. Additionally, Substance P is utilized in studies on gastrointestinal disorders, as it influences gut motility and secretion. It also plays a role in research on emotional and stress-related behaviors due to its presence in brain regions associated with mood regulation.