CRF(6-33)(human) is a synthetic peptide fragment of human corticotropin-releasing factor (CRF), consisting of amino acids 6-33, which functions as a competitive antagonist at CRF receptors. It is primarily used in research settings to study the role of the CRF system in the body by blocking CRF signaling. This helps scientists understand stress responses, as CRF is a key hormone involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis. The peptide is often utilized in experiments to investigate the effects of CRF blockade on anxiety, depression, and other stress-related disorders. Additionally, it serves as a tool to explore potential therapeutic targets for conditions linked to CRF dysregulation, such as mood disorders and neurodegenerative diseases. Its application is crucial in advancing knowledge of neuroendocrinology and developing treatments for stress-related illnesses.