Raphin1 is primarily used in research settings for its selective activation of the integrated stress response (ISR) pathway, specifically through the modulation of protein phosphatase 1 (PPP1). Its main application lies in studying cellular stress mechanisms and protein homeostasis. Due to its ability to cross the blood-brain barrier, Raphin1 is particularly valuable in neuroscience research, where it helps investigate neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and prion diseases. By restoring translational control in stressed cells, it shows potential as a tool compound for understanding how reducing chronic ISR activation can protect neurons. Raphin1 is not used clinically but serves as an important probe for validating the ISR as a therapeutic target in preclinical models.