PD-118057 is a selective activator of the KCNQ2/Q3 potassium channels, which play a key role in regulating neuronal excitability. Its primary application lies in neuroscience research, where it is used to study the function and modulation of voltage-gated potassium channels involved in controlling action potential firing in neurons. By enhancing the M-current generated by KCNQ2/Q3 channels, PD-118057 reduces neuronal hyperexcitability, making it a valuable tool for investigating potential therapeutic strategies for epilepsy and other seizure disorders. It has also been used to explore mechanisms underlying neuropathic pain and anxiety, where dysregulation of neuronal excitability is a contributing factor. Due to its specificity, PD-118057 helps researchers assess the physiological and pathophysiological roles of KCNQ channels without affecting other major ion channel types.