Prionoid E is primarily used in research settings for studying protein misfolding and aggregation processes linked to neurodegenerative diseases. It serves as a molecular probe to investigate the mechanisms of prion-like behavior in proteins, particularly in models of Alzheimer's, Parkinson's, and other amyloid-related disorders. Its ability to induce conformational changes in specific cellular proteins makes it valuable for exploring disease progression and potential therapeutic interventions. Prionoid E is also employed in high-throughput screening assays to identify compounds that can inhibit or modulate abnormal protein propagation, supporting drug discovery efforts in neuroscience. Due to its stability and detectability in biological systems, it is useful in cellular and in vitro studies aiming to visualize and quantify protein aggregation dynamics.