PPT is a potent and selective agonist for the TRPV1 receptor, which plays a key role in pain sensation and thermoregulation. It is widely used in neuroscience and pharmacology research to study pain pathways and the function of sensory neurons. Due to its ability to specifically activate TRPV1 channels, PPT is employed in experimental models to induce controlled pain responses, helping researchers evaluate potential analgesic compounds. It is also used in studies exploring neurogenic inflammation and the release of neuropeptides such as substance P. Its selectivity makes it a valuable tool for probing TRPV1 receptor activity without affecting related ion channels.