Piperenone is primarily used in research settings as a bioactive compound due to its structural similarity to piperine, the active component of black pepper. It serves as a key intermediate in the synthesis of analogs for pharmacological studies, particularly those exploring anti-inflammatory, antioxidant, and neuroprotective effects. Its ability to modulate enzyme activity and cellular pathways makes it valuable in drug discovery, especially in developing treatments for metabolic and neurological disorders. Additionally, piperenone is used to investigate mechanisms of bioavailability enhancement, similar to piperine’s role in improving the absorption of other compounds.