Used in the synthesis of pharmaceutical intermediates, particularly in the development of cannabinoid receptor modulators. Its structure supports high selectivity and metabolic stability, making it valuable in creating analogs for pain management and neurological disorder research. The difluorocyclopropane moiety enhances lipophilicity and bioavailability, which improves blood-brain barrier penetration. Commonly employed in medicinal chemistry for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic profiles.