Used primarily as a TRPV1 (transient receptor potential vanilloid 1) antagonist in research settings, AC 1903 helps in studying pain pathways and thermoregulation. It is valued for its selectivity and potency in blocking capsaicin-induced responses, making it a useful tool compound in neuroscience and pharmacology for investigating sensory neuron function and developing potential analgesic therapies. Its application extends to in vitro and in vivo models to explore inflammatory and neuropathic pain mechanisms without activating the receptor, allowing for clearer interpretation of TRPV1-related signaling.