AZD1080 is primarily used in scientific research for its potent and selective inhibition of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple cellular signaling pathways. Its application lies in studying neurological and psychiatric disorders, particularly due to GSK-3's role in neurodegeneration and mood regulation. Researchers use AZD1080 to explore potential therapeutic mechanisms in conditions such as Alzheimer's disease, bipolar disorder, and schizophrenia. It has also been investigated for its effects on cognitive function and neuroprotection in preclinical models. Due to its ability to cross the blood-brain barrier effectively, AZD1080 is a valuable tool compound in central nervous system drug development.