SB228357 is a potent and selective antagonist of the serotonin 5-HT_2B receptor, primarily used in research settings to study and understand the role of this receptor in the central nervous system and other physiological processes. It is often employed in pharmacological studies to explore its effects on neurotransmitter systems, particularly in relation to neurological disorders such as depression and anxiety, as well as cardiovascular conditions like cardiac fibrosis. The compound is valuable for investigating 5-HT_2B receptor binding properties, signaling pathways, and downstream effects, aiding in the development of therapeutic agents for CNS-related diseases and other pathologies. Its application is limited to experimental and preclinical studies, contributing to advancements in neuroscience, pharmacology, and drug discovery.