K145 hydrochloride is a selective inhibitor of sphingosine kinase 2 (SphK2), exhibiting high selectivity over SphK1. Primarily used in research settings, this compound is investigated for its potential therapeutic effects across multiple fields, including neuroscience, oncology, and inflammation. In neuroscience, it modulates S1P signaling pathways by reducing S1P production, which may influence specific receptors in the brain and have implications for treating neurological disorders such as anxiety, depression, or cognitive impairments. It also shows promise in inhibiting tumor growth and inflammatory responses in cancer and related pathologies. Additionally, it serves as a valuable tool in pharmacological studies to better understand enzyme inhibition, receptor interactions, and signaling pathways. Its applications are largely experimental, with ongoing studies to explore its efficacy and safety in various biological models.